{"type":"standard","title":"AM-938","displaytitle":"AM-938","namespace":{"id":0,"text":""},"wikibase_item":"Q4652508","titles":{"canonical":"AM-938","normalized":"AM-938","display":"AM-938"},"pageid":17361788,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/c/c9/AM-938_Structure.svg/320px-AM-938_Structure.svg.png","width":320,"height":169},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/c/c9/AM-938_Structure.svg/197px-AM-938_Structure.svg.png","width":197,"height":104},"lang":"en","dir":"ltr","revision":"1252439370","tid":"f336587b-8f98-11ef-a38a-358d51121ba7","timestamp":"2024-10-21T10:40:55Z","description":"Chemical compound","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/AM-938","revisions":"https://en.wikipedia.org/wiki/AM-938?action=history","edit":"https://en.wikipedia.org/wiki/AM-938?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:AM-938"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/AM-938","revisions":"https://en.m.wikipedia.org/wiki/Special:History/AM-938","edit":"https://en.m.wikipedia.org/wiki/AM-938?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:AM-938"}},"extract":"AM-938 (part of the AM cannabinoid series) is an analgesic drug which is a cannabinoid receptor agonist. It is a derivative of HU-210 which has been substituted with a 6β-(3-hydroxyprop-1-ynyl) group. This adds a \"southern\" aliphatic hydroxyl group to the molecule as seen in the CP-series of nonclassical cannabinoid drugs, and so AM-938 represents a hybrid structure between the classical and nonclassical cannabinoid families, with the 6-hydroxyalkyl chain rigidified with a triple bond. This gives AM-938 a greater degree of selectivity, so while it is still a potent agonist at both CB1 and CB2, it is reasonably selective for CB2, with a Ki of 0.3 nM at CB2 and 1.2 nM at CB1, a selectivity of around four-fold.","extract_html":"
AM-938 (part of the AM cannabinoid series) is an analgesic drug which is a cannabinoid receptor agonist. It is a derivative of HU-210 which has been substituted with a 6β-(3-hydroxyprop-1-ynyl) group. This adds a \"southern\" aliphatic hydroxyl group to the molecule as seen in the CP-series of nonclassical cannabinoid drugs, and so AM-938 represents a hybrid structure between the classical and nonclassical cannabinoid families, with the 6-hydroxyalkyl chain rigidified with a triple bond. This gives AM-938 a greater degree of selectivity, so while it is still a potent agonist at both CB1 and CB2, it is reasonably selective for CB2, with a Ki of 0.3 nM at CB2 and 1.2 nM at CB1, a selectivity of around four-fold.
"}{"fact":"A cat cannot see directly under its nose.","length":41}
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{"slip": { "id": 45, "advice": "Build something out of LEGO."}}
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